27.5kg Pure Tianeptine Sodium In Stock

FOB Price 3000 - 4000 USD / kg

MOQ	1 kg
Port	any port in China
Lead Time	4 days

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MSDS	Yes	Standards	EP9.0
COA	Yes

Product Details

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What is Tianeptine Sodium Powder?

Tianeptine Sodium powder is used as an atypical antidepressant for the treatment of the major depressive disorder. It is also used to treat anxiety, asthma, and irritable bowel syndrome. It is one of our most competitive pharmaceutical ingredients in stock. It is marketed as Stablon and Coaxil.

Tianeptine sodium is also used for treating pain caused by fibromyalgia due to its anticonvulsant and analgesic effects. Tianeptine has been effective in the treatment of attention-deficit hyperactivity disorder with minimal side effects too.

Is Tianeptine sodium Nootropic?

The answer is Yes.

Nootropics, also known as smart drugs, are used to improve cognitive function, particularly executive functions, memory, creativity, or motivation in healthy individuals.

Tianeptine is a TCA-like and serotonergic enhancing medication prescribed commonly in the Middle East and Europe for depression and anxiety. However, the study shows it does help to improve people’s cognitive functions.

The FDA hasn’t approved Tianeptine for any use in the United States for any conditions, let alone allow it to be used to improve cognitive functions.

Tianeptine Sodium vs Sulfate (6 main differences)

There are three commonly seen Tianeptine forms on the market: Tianeptine acid, tianeptine sodium, and tianeptine sulfate.

Among them, tianeptine acid is the least popular and cheapest type. Maybe tianeptine free acid only exists because it can be made into various tianeptine salts such as tianeptine hydrochloride, tianeptine tosylate, tianeptine phosphate, etc. So here we only list the difference between tianeptine sodium and tianeptine sulfate (also written as tianeptine sulphate).

1. Their age. (Tianeptine Sodium is older than sulfate)

Tianeptine sodium is the first to be widely used for medical purposes for depression since 1960. Tianeptine sulfate is later-developed and improved versions to replace tianeptine sodium.

2. Stability. (tianeptine sulfate is more stable than tianeptine sodium)

Both tianeptine sodium and sulphate are stable when protected from light and air. But sodium salt is very hygroscopic to get chunky. While tianeptine sulfate salt contains monohydrate with itself, it is more stable when exposed to air for a short period.

3. Water solubility uniformity. (Tianeptine sulfate has better uniformity than sodium)

In water solutions PH ranged 1~6, the soluble amount of tianeptine sulphae in water is very average. Its solubility curve is very smooth, the value gets slightly smaller as the PH goes up. While sodium salt has a sudden drop when PH goes from 1 to 6. As the stomach fluid PH ranges from 1.5~3.5 and sure you will choose sulphate to maintain a stable solubility.

4. Taste. (Tianeptine sulfate is not bitter, sodium is)

The bitterness of tianeptine sodium can linger in your mouth for one month if you take the API directly. While tianeptine sulphate is much better on the taste, no such strong bitterness at all.

That’s why you only see tianeptine sodium capsules but rarely see any tianeptine sodium tablets on the market.

5. Half-life and Bioavailability. (Tianeptine sulfate lasts longer than sodium)

According to researches and online reviews, tianeptine sulphate performs better on both half-life and bioavailability. Sulphate is easier to absorb and its effect lasts longer, while dosing sodium can go to 6~7 times daily to obtain the same effect as sulphate.

6. Price. (Tianeptine Sulfate is 20% higher than sodium)

As tianeptine sulfate has better performance almost on any aspect than tianeptine sodium and the production process is a little more complicated, its price is also a little higher, which does make sense.

Tianeptine VS Trazodone

Tianeptine sodium vs trazadone on chemical structure

Both Trazodone and Tianeptine can be used for the treatment of depression. What are their differences?

Trazodone is an antidepressant agent. It affects chemicals in the brain that may be unbalanced in people with depression.

Trazodone is mainly used to treat the major depressive disorder. It may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression. Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain.

Trazodone has been approved for medical use in the United States in 1981, while Tianeptine has not been prescribed for any indications in the United States until today.

What are Tianeptine Sodium Side Effects?

Common side effects(>1% frequency)

Headache (up to 18%) / Dizziness (up to 10%) / Insomnia/nightmares (up to 20%) / Drowsiness (up to 10%) / Dry mouth (up to 20%) / Constipation (up to 15%) / Nausea / Abdominal pain / Weight gain (~3%) / Agitation / Anxiety / irritability

Uncommon side effects(0.1-1% frequency)

Bitter taste / Flatulence / Gastralgia / Blurred vision / Muscle aches / Premature ventricular contractions / Micturition disturbances / Palpitations
Orthostatic hypotension / Hot flushes / Tremor Rare (<0.1% frequency) / Hepatitis / Hypomania / Euphoria / ECG changes / Pruritus / allergic-type / skin reactions / Protracted muscle aches

Warnings (tianeptine sodium withdrawal)

According to tianeptine marketer Servier, stopping of treatment with tianeptine is difficult, due to the possibility of withdrawal symptoms in a person. The severity of the tianeptine withdrawal is dependent on the daily dose, with high doses being extremely difficult to quit. DEA states that the withdrawal symptoms in humans typically result in agitation, nausea, vomiting, tachycardia, hypertension, diarrhea, tremor, and diaphoresis.

Data are demonstrating that the abuse of tianeptine is increasing while contributing to the current opioid epidemic.