Cas number: 1405-20-5
Molecular Formula: C56H100N16O17S
Molecular Weight: 1301.6 g/mol
Polymyxin B Sulfate is a white to off-white
powder derived from the bacterium Bacillus
polymyxa. It is one of our strategic active
pharmaceutical ingredients for dermal
ointments.
There are two types of Polymyxins:
Polymyxin B and Polymyxin E(also known as
colistin). Polymyxin B is composed of
polymyxins B1, B1-I, B2, B3, and B6.
Polymyxins B1 and B2 are considered major
components. These related components are
structurally identical except for a
different fatty acid group on each
fraction. Results from in vitro studies
have shown marginal differences in MIC data
when comparing the fractions.
Mechanism of Polymyxin B’s Bactericidal
Effects is as below: Polymyxin B binds to
the cell membrane and alters its structure,
making it more permeable. The resulting
water uptake leads to cell death of
bacteria. Polymyxin B is a cationic basic
peptide that acts like detergent.
Polymyxin B can be used for urinary tract
infections and meningitis as it exerts
bactericidal effects against almost all
Gram-negative bacilli except the Proteus
and Neisseria genera.