Mainly used as a gasoline additive, it has excellent anti-knock properties, increases octane number, and can also be cracked to produce isobutylene. It has good miscibility with gasoline, absorbs less water, and has no pollution to the environment. It can be used as an analytical solvent and extraction agent. It is used as a stripping agent in chromatography, especially high-pressure liquid chromatography, and can be used with some polar solvents such as water, methanol, Ethanol forms an azeotrope. Methyl tert-butyl ether also has a mild anesthetic effect.