|
Pharmacological action
|
Mecobalamin as vitamin B12
derivatives, should be called "methyl vitamin B12"
according to the chemical structure of name, the functional
groups of methylation can be involved in the biochemical
process of methyl transfer activity, promoting to nucleic
acid of nerve tissue, the metabolism of protein and fat, ,
can stimulate the synthesis of lecithin Schwann cells,
repairing the damaged myelin, improving nerve conduction
velocity; directly into nerve cells, and stimulating axon
regeneration of damaged area; stimulating protein synthesis
in nerve cells and enhanced synthetic metabolism of axons
to prevent axonal degeneration; involved in nucleic acid
synthesis, promoted hematopoietic function. The treatment
is clinically used in diabetic neuropathy, long-term use of
macrovascular complications of diabetes are the curative
effect.
Mecobalamin is used for peripheral nerve disorders
treatment drug, compared with other vitamin B12
preparations, having good transfer on the nervous tissue,
through the methyl transfer reaction, can promote nucleic
acid, protein lipid metabolism, repairing the damaged nerve
tissue. In homocysteine synthetic egg ammonia acid process,
it plays a role of coenzyme, especially by deoxyuridine
synthesis of thymidine, promoting DNA and RNA synthesis of
participation. Also in the experiment of glial cells, the
drugs can improve methionine synthase activity and promote
the synthesis of myelin lipids lecithin. Improving the
nerve tissue metabolism, can promot axis cable and protein
synthesis, make the delivery rate of the skeletal protein
close to normal, maintain axonal functions. Besides
mecobalamin injections can inhibit nerve tissue of abnormal
impulse conduction, promoting redl blood cells mature,
split, improving anemia. Mecobalamin can be quickly
restored due to lack of B12 and reduce the number of rat
erythrocytes, hemoglobin, hematocrit value. Used for
megaloblastic red blood cell anemia and peripheral nerve
disorder due to the lack of vitamin B12.
The above information is edited by the Chemicalbook
Hanya.
|
|
Uses
|
1.It is used for the
treatment of nervous system diseases, relieving pain and
numbness, speeded relieving pain, improving pain caused by
cervical spondylosis, treatment of sudden deafness,
etc.
2.Methylcobalamin is a kind of endogenous coenzyme B12,
participating in the one carbon unit cycle, playing an
important role in the synthesis of methionine homocysteine
methyl transfer reaction process.
|
|
Chemical Properties
|
Dark Red Crystalline
Powder
|
|
Physical properties
|
Vitamin B12 is an octahedral
cobalt complex consisting of a porphyrin-like, cobalt
centered macroring (called a corrin ring or nucleus). The
corrinoids are red, red orange, or yellow crystalline
substances that show intense absorption spectra above 300
nm owing to the π–π transitions of the corrin nucleus. They
are soluble in water and are fairly stable to heat but
decompose at temperatures above ～210 °C without
melting.
Vitamin B12 reacts with ascorbic acid, resulting in the
reduction and subsequent degradation of the former, which
releases its cobalt atom as the free ion. Cobalamins are
more stable in the presence of ascorbic acid but unstable
to light
|
|
Uses
|
One of the biologically
active forms of vitamin B12; differing only by the
substitution of a methyl for the cyano group. Coenzyme
required in the biosynthesis of methionine. Vitamin
(hematopoietic).
|
|
Uses
|
?Histamine receptor,
Alzheimer research
|
|
Definition
|
A vitamin B 12 analog used as
an intermediate in the synthesis of methane. It is
responsible for the methylation of inorganic mercury by
anaerobic bacteria in bottom sediments. Through the action
of methylcobalamin in an anaerobic bacteria in bottom
sediments of aquatic systems, arsenic(III) is methylated to
methanearsonic acid then to cacodylic acid.
|
Member's Area
Messages 
Need Help
Browse Through Millions of High-Quality Products. 