ION Channel Profiling|GPCR

Product Details

The Ephys department in ICE offers a large collection of validated, ready-to-use ion channel panel assay for screening and research

We have 100+ ion channel expressing cell line in ICE for target identification, secondary screening, preclinical development and basic research.

Moreover, several types of primary cell isolation and electrophysiological service are available.

The list for ion channel Portfolio -- continuously expanding

Ø Voltage gated ion channel

Voltage gated sodium channel

Nav1.1: assay format--1,2; Nav1.2: assay format--1,2;

Nav1.3: assay format--1,2; Nav1.4: assay format--1,2;

Nav1.5: assay format--1,2; Nav1.6: assay format--1;

Nav1.7: assay format--1; Nav1.8: assay format--1;

Voltage gated calcium channel

Cav1.2: assay format--1; Cav3.2: assay format--1;

Voltage gated potassium channel

hERG: assay format--1,2,3; IKs (KCNQ1 /KCNE1): assay format--1

KCNQ2/3: assay format--1,2;

KCNQ2/4: assay format--1;

KCNQ3/5: assay format--1; KCNQ2-5: assay format--1 ;

Kv1.1-1.5: assay format--1; Kv2.1: assay format--1;

Kv3.1-3.2: assay format--1; Kv3.4: assay format--1;

Kv4.2: assay format--1; Kv4.3: assay format--1;

Two-pore domain potassium channel

TREK1: assay format--1;

TASK1: assay format--1;

TASK3: assay format--1;

Inward-rectifier potassium channels

Kir6.2/SUR2A & Kir6.2/SUR1: assay format--1

Kir2.1: assay format--1; Kir3.1/3.4 (Kach): assay format--1;

Kir3.2 (GirK2): assay format--1; Kir4.1assay format--3;

Acid sensitive ion channels

ASIC1a: assay format--1;

ASIC3 assay format--1;

Calcium-activated potassium channels

SK1-3: assay format--1;

BKα1β1/4: assay format--1

Ik1(KCNN4): assay format--1;

Chloride channel

CFTR: assay format--1;

TMEM16A (ANO-1): assay format--1;

TMEM16B (ANO-2): assay format--1;

Hyperpolarization-activated cyclic nucleotide-gated ion channel

HCN1: assay format--1;

HCN2: assay format--1;

HCN4: assay format--1;

Ø ligand gated ion channel

GABA-A receptor

GABAA(α1β2γ2):assay format--1; GABAA(α2β3): assay format--1;

GABAA(α3β3) : assay format--1; GABAA(α4β3) : assay format--1;

TRP receptor

TRPA1: assay format--1; TRPV1: assay format--1;

TRPV4: assay format--1,3; TRPV3: assay format--1;

TRPC6: assay format--1,3; TRPC7: assay format--1;

TRPM8: assay format--1; TRPM4/SUR1: assay format--1;

P2X receptor

hP2X2/3: assay format--1.3; rP2X2/3: assay format--1.3

gpP2X2/3: assay format--1;

hP2X3: assay format--1; rP2X3: assay format--1,3;

gpP2X3: assay format--1;

P2X7: assay format--1.3;

nAChR receptor

nAChR-(α1)2β1δε ：assay format--TEVC;

nAChR-α3β4: assay format--1; nAChR-α4β2:assay format--1,2,3;

NMDA receptor

NR1/NR2A: assay format--1; NR1/NR2B: assay format--1;

rNR1/NR2A: assay format--1; rNR1/NR2B: assay format--1;

NR1/NR2C: assay format--1; NR1/NR2D: assay format--1;

others

5-HT3A: assay format--1,2,3;

GlyRα1/β: assay format--

Ø Note for assay format

Assay format--1: Manual patch clamp

Assay format--2: Qpacth

Assay format--3: FLIPR assay