Human PDGF(Platelet-Derived Growth Factor) ELISA Kit

Product Details

Human PDGF(Platelet-Derived Growth Factor) ELISA Kit

Key words: PDGF(Platelet-Derived Growth Factor) ELISA

A,Introduction

Feiyue's Human PDGF (Platelet-Derived Growth Factor) ELISA Kit

is an ELISA reagent for detection PDGF (Platelet-Derived Growth Factor)in human serum, plasma or cell with sensitivity, specificity and consistency.

Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).

PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In both mouse and human, the PDGF signalling network consists of five ligands, PDGF-AA through -DD (including -AB), and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers.

This kit uses sandwich ELISA to detect the concentration of human PDGF.

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References

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3, The Basic Biology of Platelet Growth Factors. [2014-05-08].

4, Kumar, Vinay. Robbins and Coltran Pathologic Basis of Disease. China: Elsevier. 2010: 88–89. ISBN 978-1-4160-3121-5.

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