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CAS NO:61438-64-0
Description:Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing.
In Vitro:Closantel sodium, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Wanjia Breeding and Logistics Park, Babao, Zhengzhou City
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