MOQ | 1 kg |
Packaging | Aluminum foil bag |
Lead Time | 15~30 |
White powder | 1000 |
Vardenafil alcohol soluble vardenafil
Name: vardenafil hydrochloride, vardenafil hydrochloride, vardenafil hydrochloride
alias: vardenafil hydrochloride
English Name: vardenafil hydrochloride
English alias: 2 - [2-ethoxy-5 - (4-ethylpiperazin-1-yl) sulfonylphenyl] - 5-methyl-7-propyl-1h-imidazo [5,1-f] [1,2,4] triazin-4-one hydrochloride; 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one dihydrochloride
CAS No.: 224785-91-5
Molecular formula: c23h34cl2n6o4s
Molecular weight: 561.5249
Purity: ≥ 99.65%
Loss on drying: < 0.5%
Heavy metal: less than 20 ppm
Boiling point: 692.2 ° C at 760 mmHg
Flash point: 372.5 ° C
Vapor pressure: 5.17e-19mmhg at 25 ° C
Solubility: soluble in wine and water.
Character: white powder with high purity, light yellow and bitter taste
Purpose: for export only. The latest drugs in the field of erectile dysfunction (ED) treatment
Package: 1kg / aluminum foil bag, 25kg / sealed cardboard Bucket & double plastic package.
Storage: keep in a dry place, avoid strong light and high temperature
Research data of alcohol soluble vardenafil raw materials:
Usage and dosage: oral.
1. Recommended dose: the recommended starting dose is 10mg, about 25-60 minutes before sex. In clinical trials, taking it 4-5 hours before sexual intercourse still showed efficacy. The maximum recommended dose is once a day. Vardenafil can be taken with food or alone. Sexual stimulation is needed as an instinctive response to treatment.
2. Dose range: according to the efficacy and tolerance, the dose can be increased to 20mg or reduced to 5mg. The maximum recommended dose is 20 mg per day.
3. Liver damage: Patients with mild liver damage (child Pugh a) do not need to adjust the dose; For patients with moderate liver injury (child Pugh b), the initial dose of vardenafil is recommended to be 5mg due to the decrease of clearance rate, and then it is gradually increased to 10mg according to the tolerance and efficacy; The pharmacokinetics of vardenafil in patients with severe liver injury (child Pugh C) has not been studied.
4. Renal damage: Patients with mild, moderate or severe renal damage do not need dose adjustment. The pharmacokinetics of vardenafil in dialysis patients has not been studied.
5. Drug combination: some patients take vardenafil and dexamethasone at the same time α- Receptor blockers may cause symptomatic hypotension. Only when the patient accepts α- Only when the patient's condition is stable, can the combination therapy be used. For acceptance α- In the treatment of stable patients with receptor blocker, the dosage of vardenafil should be the minimum recommended initial dose of 5mg, and can be taken at any time
Precautions for alcohol soluble vardenafil: as sexual activity is associated with a certain degree of heart risk, doctors should first consider the heart condition of patients with erectile dysfunction before taking any treatment. The vasodilative properties of vardenafil may lead to a temporary mild decrease in blood pressure. Patients with left ventricular outflow dysfunction, such as aortic stenosis and idiopathic hypertrophic subaortic stenosis, may be sensitive to vasodilators, including PDE5 inhibitors. Due to the potential cardiac risk, it is not recommended for patients with heart disease to use it. Therefore, drugs for erectile dysfunction cannot be used. A study of the effect of vardenafil on QT interval in 59 healthy male subjects showed that vardenafil at a therapeutic dose (10.5 mg) and an overdose (80 mg) resulted in prolonged QTc interval. This should be taken into account in the clinical application of vardenafil.