Pharmaceutical grade Dimethyl Sulfoxide
DMSO
Dimethyl
sulfoxide (abbreviated DMSO) is a sulfur-containing organic
compound; molecule formula: (CH3) 2SO; It exhibits as
colorless, odorless, hygroscopic and flammable transparent
liquid at room temperature. It has both high polarity as well
as high-boiling point. It also has aprotic and water-miscible
characteristics. It has low toxicity, good thermal stability,
and is not miscible with paraffin. It is soluble in water,
ethanol, propanol, ether, benzene and chloroform and many other
kinds of organic substance and is called as the "universal
solvent." It is a common organic solvent which has the
strongest dissolving ability. It can dissolve most the organic
compounds including carbohydrates, polymers, peptides, as well
as many inorganic salts and gases. It can dissolve certain
amount solute whose weight is equals to 50-60% of itself (other
common solvents usually only dissolve 10-20%), so it is very
important in the sample management as well as high-speed
screening of drugs. Under certain conditions, contact between
dimethyl sulfoxide and chloride can even lead to explosive
reaction.
Dimethyl
sulfoxide is widely used as solvents and reagents, particularly
as the processing reagent and spinning solvent at the reaction
of acrylonitrile polymerization used for polyurethane synthesis
and the spinning solvent. It can also be used as the synthetic
solvent for polyamide, polyimide and polysulfone resin as well
as the extraction solvents for aromatic hydrocarbon and
butadiene extraction solvents and solvents for synthesizing
chlorofluoroaniline. In addition, dimethyl sulfoxide can also
be directly used as the raw material or carrier of some drug in
the pharmaceutical industry. dimethyl sulfoxide itself has
various effects such as anti-inflammatory, analgesic, diuretic,
and sedative, and thus also being known as "panacea" which is
usually as the active ingredient of analgesic medication being
added to the drug. It also has special properties of easy
penetration through the skin, resulting in personnel feeling of
oyster-like flavor. The dimethyl sulfoxide solution of sodium
cyanide can cause cyanide poisoning through skin contact while
dimethyl sulfoxide itself has a relative low toxicity. dimethyl
sulfoxide is widely applied as the extraction agent in a lot of
chemical and pharmaceutical companies. However, because of its
higher boiling point, it causes very high operating
temperatures and further causes the coking of materials, thus
affecting the recycling of dimethyl sulfoxide and further
cleaning of the equipments as well as resulting in increased
energy consumption. Therefore, the recycling of dimethyl
sulfoxide has become a bottleneck as its further wide
application as extraction agent.
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